Thompson H W, McCarthy L J
Arch Intern Med. 1983 Nov;143(11):2117-9. doi: 10.1001/archinte.143.11.2117.
Two patients with thrombotic thrombocytopenic purpura (TTP) were treated with a combination of antiplatelet drugs, corticosteroids, and plasma exchange. There was immediate clinical and laboratory improvement in both patients. However, the improvement did not persist following plasma exchange, even with infusions of fresh frozen plasma. Splenectomy was performed on both patients with subsequent sustained remission of the disease. Platelet counts returned to normal within eight days (case 1) and five days (case 2). Follow-up at eight months in one patient and at four months in the other disclosed normal laboratory values with no evidence of recurrent TTP. These cases suggest that in addition to other therapies, splenectomy may be beneficial in some patients.
两名血栓性血小板减少性紫癜（TTP）患者接受了抗血小板药物、皮质类固醇和血浆置换的联合治疗。两名患者均立即出现临床和实验室指标改善。然而，即使输注新鲜冰冻血浆，血浆置换后这种改善也未持续。两名患者均接受了脾切除术，随后疾病持续缓解。血小板计数在8天内（病例1）和5天内（病例2）恢复正常。一名患者随访8个月，另一名患者随访4个月，实验室检查值均正常，无TTP复发迹象。这些病例表明，除其他治疗方法外，脾切除术可能对某些患者有益。
