多米多醇；顺式和反式异构体的分离及其药理活性比较。
Domiodol; separation of cis and trans isomers and comparison of their pharmacological activity.
作者信息
Riva M, Gentili P, Kogi K, Saito T, Cantarelli G, Ravenna F
出版信息
Arzneimittelforschung. 1983;33(8):1091-3.
PMID:6685484
Abstract
Cis and trans isomers of 2-iodomethyl-4-hydroxymethyl-1,3-dioxolane (domiodol, MG 13 608) were separated by preparative GLC and prepared on a larger scale by previous resolution of an intermediate. Acute toxicity and effect on respiratory tract excretion were evaluated for domiodol and for each isomer: no significant differences were found.
摘要
2-碘甲基-4-羟甲基-1,3-二氧戊环（多碘醇，MG 13 608）的顺式和反式异构体通过制备型气相色谱法分离，并通过先前对中间体的拆分进行大规模制备。对多碘醇及其每种异构体的急性毒性和对呼吸道排泄的影响进行了评估：未发现显著差异。
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