Heuer H, Gülker H, Thale J, Meyer M, Weiss U, Bendeer F
Arzneimittelforschung. 1983;33(8):1113-6.
In experiments on 20 artificially ventilated anaesthetized dogs, the effects of the new calcium antagonist diltiazem on the stimulation thresholds to repetitive extrasystoles and fibrillation of the atria and the ventricles, respectively, and on ventricular dysrhythmias 6-24 h after acute coronary occlusion were investigated. The electrophysiological studies were performed using different methods of programmed stimulation of the heart. The results show that therapeutic doses of diltiazem provide no protection against stimulus-induced supraventricular reentrant arrhythmias with the AV-node not involved in the reentrant circus, and have no antifibrillatory efficacy in electrically induced ventricular arrhythmias in the non-ischemic heart. In acute myocardial infarction there is no antiarrhythmic effect either. Our results can be explained by the fact that diltiazem is a specific calcium antagonist and that the slow response plays only a minor role in the arrhythmias investigated.
在对20只人工通气的麻醉犬进行的实验中，研究了新型钙拮抗剂地尔硫䓬分别对心房和心室重复期前收缩及颤动的刺激阈值，以及急性冠状动脉闭塞后6 - 24小时对心室心律失常的影响。使用不同的心脏程控刺激方法进行电生理研究。结果表明，治疗剂量的地尔硫䓬对不涉及折返环的房室结无关的刺激诱发室上性折返性心律失常没有保护作用，对非缺血性心脏电诱发的室性心律失常没有抗纤颤效果。在急性心肌梗死中也没有抗心律失常作用。我们的结果可以通过以下事实来解释：地尔硫䓬是一种特异性钙拮抗剂，并且慢反应在所研究的心律失常中仅起次要作用。
