[14C-1-赤藓醇去甲麻黄碱及其N-取代产物14C-奥昔非君和14C-D 13,625的合成]
[Syntheses of 14C-1-erythro-norephedrine and its N-substitution products 14C-oxyfedrine and 14C-D 13,625].
作者信息
Bickel E, Engel J, Klingler K H
出版信息
Arzneimittelforschung. 1983;33(9):1213-5.
PMID:6685500
Abstract
Starting from 14C-benzene (--)-erythro-norephedrine (14C-1-norephedrine) was obtained in a 6-step synthesis. 14C-1-Norephedrine functioned as an intermediate for the synthesis of the carbon labelled partial beta-agonist oxyfedrine hydrochloride (ildamen) and the new positive inotropic agent D 13 625 (alifedrine hydrochloride).
摘要
从14C-苯开始，通过6步合成得到了（-）-赤藓醇去甲麻黄碱（14C-1-去甲麻黄碱）。14C-1-去甲麻黄碱作为合成碳标记的部分β-激动剂盐酸奥昔非君（伊达明）和新型正性肌力药物D 13 625（盐酸阿利非君）的中间体。
Zotero 插件