Rusakov D Iu, Val'dman A V
Biull Eksp Biol Med. 1983 Nov;96(11):62-4.
In experimental learned helplessness in mice determined by preliminary inavoidable aversive exposure, activity of tricyclic antidepressants (desipramine, chlorimipramine, amitryptyline), type A MAO inhibitors (pyrazidol), and atypical (zimelidine, trazodon, befuralin) antidepressants as well as that of potential antidepressants (LIS-30, DZK-153) were determined upon chronic administration. The tricyclic compounds, befuralin and DZK-153 removed learned helplessness only after 14 days of administration. The substances with a predominant serotoninomimetic action (zimelidin, trazodon in high doses, pyrazidol, LIS-30) showed high efficacy following 6 days of administration. Single administration of the substances under study did not make it possible to disclose their specific antidepressant activity.
在通过初步不可避免的厌恶暴露确定的小鼠实验性习得性无助中，在长期给药后测定了三环类抗抑郁药（地昔帕明、氯米帕明、阿米替林）、A型单胺氧化酶抑制剂（吡唑醇）、非典型抗抑郁药（齐美利定、曲唑酮、贝氟林）以及潜在抗抑郁药（LIS - 30、DZK - 153）的活性。三环类化合物、贝氟林和DZK - 153仅在给药14天后消除了习得性无助。具有主要血清素模拟作用的物质（齐美利定、高剂量曲唑酮、吡唑醇、LIS - 30）在给药6天后显示出高疗效。所研究物质的单次给药无法揭示其特定的抗抑郁活性。
