Palm T, Nielsen S L, Lassen N A
Clin Physiol. 1983 Oct;3(5):433-44. doi: 10.1111/j.1475-097x.1983.tb00851.x.
Water filtration in the human forearm was determined with a new method using a hyperoncotic transient of albumin solution infused into the brachial artery. Baseline dilution of labelled albumin in deep forearm vein plasma in excess of the contribution from arterial blood and from infusate was assumed to originate from extravascular water filtered into the blood by the transient. The filtration coefficient (Fc) was determined as the ratio between filtered water and increase in colloid osmotic pressure in the blood samples, and gives the filtrative water permeability in the exchange areas of the microcirculation. In 10 normal volunteers, Fc was 0.00082 ml (ml mmHg)-1 (SD=0.00007). Multiplication of Fc by plasma flow in the forearm gave a filtration capacity (Kf) of 0.0036 ml (100 ml tissue min mmHg)-1 (SD=0.00137). This filtration capacity (Kf) represents that of fast flowing regions in the forearm muscles, but it is of the same order of magnitude as the capillary filtration coefficient (CFC) determined plethysmographically for the entire forearm by the venous stasis technique.
采用一种新方法测定人体前臂的水滤过情况，该方法利用注入肱动脉的白蛋白溶液产生的高渗瞬变。假定前臂深部静脉血浆中标记白蛋白的基线稀释度超过动脉血和注入液的贡献，是由该瞬变导致血管外水滤入血液所致。滤过系数（Fc）定义为滤过水与血样中胶体渗透压升高的比值，它反映了微循环交换区域的滤过水通透性。在10名正常志愿者中，Fc为0.00082 ml（ml mmHg）-1（标准差 = 0.00007）。Fc与前臂血浆流量相乘得出滤过能力（Kf）为0.0036 ml（100 ml组织·分钟·mmHg）-1（标准差 = 0.00137）。这种滤过能力（Kf）代表了前臂肌肉中快速流动区域的滤过能力，但与通过静脉淤滞技术体积描记法测定的整个前臂的毛细血管滤过系数（CFC）处于同一数量级。
