Gay P E, Madsen J A
Neurology. 1983 Dec;33(12):1631-2. doi: 10.1212/wnl.33.12.1631.
The effects of thioridazine (TDZ) on serum phenobarbital (PB) and phenytoin (PHT) were studied in mentally retarded persons. Persons taking these drug combinations were identified and matched on the basis of age, sex, body weight, and antiepileptic drug (AED) dosage with persons from the same population who were taking only the AEDs. Trough, steady state serum levels were obtained as part of regular AED monitoring schedules. Serum level of PB per unit dose was significantly less with concomitant administration of TDZ (100 to 200 mg/day) than when PB was given alone. This effect seemed to be TDZ dose-responsive. TDZ had no consistent effects on serum PHT.
在智力发育迟缓者中研究了硫利达嗪（TDZ）对血清苯巴比妥（PB）和苯妥英（PHT）的影响。识别出服用这些药物组合的人，并根据年龄、性别、体重和抗癫痫药物（AED）剂量与来自同一人群中仅服用AED的人进行匹配。作为常规AED监测计划的一部分，获取谷值、稳态血清水平。与单独给予PB时相比，同时给予TDZ（100至200mg/天）时，每单位剂量PB的血清水平显著降低。这种效应似乎对TDZ剂量有反应。TDZ对血清PHT没有一致的影响。
