Shaliapina V G, Chemyrtan N A
Probl Endokrinol (Mosk). 1983 Sep-Oct;29(5):55-9.
In the course of postnatal ontogeny of rats, the synthesis and secretion of corticosterone after birth first decline, then increase by the 3d week of development, reaching by puberty the level seen in adult animals. During stressor stimulation with "neurogenic" stimuli (sound, swinging), the response on the part of the pituitary-adrenal system (PAS) is detectable only at the age of 3 weeks, whereas during immobilization of the animals with paw stretching and fixation it is detectable since the first day of life. The chemical stimulants of the adrenal cortex (ACTH), of the pituitary (vasopressin) and of the hypothalamus (insulin) activate the peripheral and central components of the PAS at varying age periods and to varying degree. This indicates that during early postnatal ontogenesis, the character of a stressor stimulus and line of its effect on different components of the system play the key roles.
在大鼠出生后的个体发育过程中，出生后皮质酮的合成与分泌起初下降，随后在发育的第3周增加，到青春期达到成年动物的水平。在用“神经源性”刺激（声音、摆动）进行应激源刺激时，垂体-肾上腺系统（PAS）的反应仅在3周龄时可检测到，而在用爪子伸展和固定的方式使动物固定时，从出生第一天起就可检测到该反应。肾上腺皮质（促肾上腺皮质激素）、垂体（血管加压素）和下丘脑（胰岛素）的化学刺激物在不同年龄阶段以不同程度激活PAS的外周和中枢成分。这表明在出生后的早期个体发育过程中，应激源刺激的性质及其对系统不同成分的作用途径起着关键作用。
