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地中海实蝇细胞系:对快中子和伽马射线辐照的反应

Med-fly cell line: response to irradiations with fast neutrons and gamma-rays.

作者信息

Cavalloro R, Pozzi G, Coppola M

出版信息

Rev Can Biol Exp. 1983 Jul;42(2):109-15.

PMID:6685889
Abstract

It has been observed that biological systems have different sensitivities to various radiation qualities. Moreover, the relative response depends on the dose level of the applied radiation. In this context the radiosensitivity of Med-fly, Ceratitis capitata Wied., cells, to gamma-rays and neutrons, has been tested by observing cell population growth and mortality. Fast neutron doses ranged between 1.5 and 25 rad, a region of particular interest in radiation protection studies; the 60Co gamma-ray dose values were between 300 and 5 000 rad. The experimental results show a much higher radiosensitivity of these cells to fast neutrons than to gamma-rays, and indicate a dependence of the RBE values on the neutron-dose levels. Furthermore, there was a certain dependence on radiation quality for the morphological damage. Dose-effect relationships are analyzed for both neutrons and gamma-rays and the results are discussed.

摘要

据观察,生物系统对各种辐射性质具有不同的敏感性。此外,相对反应取决于所施加辐射的剂量水平。在此背景下,通过观察细胞群体生长和死亡率,测试了地中海实蝇(Ceratitis capitata Wied.)细胞对γ射线和中子的辐射敏感性。快中子剂量范围为1.5至25拉德,这是辐射防护研究中特别感兴趣的区域;60Coγ射线剂量值为300至5000拉德。实验结果表明,这些细胞对快中子的辐射敏感性远高于对γ射线的敏感性,并表明相对生物效应(RBE)值取决于中子剂量水平。此外,形态损伤对辐射性质有一定的依赖性。分析了中子和γ射线的剂量效应关系并讨论了结果。

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