Leuschner F, Neumann B W, Hübscher F
Arzneimittelforschung. 1983;33(10):1475-6.
The 90-day inhalation studies, conducted in 1975, showed that for the fluorocarbons the lowest toxic concentrations could be regarded above 5,000 ppm by volume of air (0.5% by vol.) when administered to Beagle dogs. With rats the lowest toxic concentrations were above 10,000 ppm by volume. Administration took place on 90 consecutive days for 6 h per day.
1975年进行的为期90天的吸入研究表明,对于碳氟化合物而言,当给比格犬使用时,最低有毒浓度可视为高于空气中体积的5000 ppm(按体积计0.5%)。对于大鼠,最低有毒浓度高于空气中体积的10000 ppm。连续90天每天给药6小时。