[Effect of prolonged hypokinesia on the biogenic amine content of rat brain synaptosomes].

Experimental data are provided on the time course of changes in the content of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) in the synaptosomes of the sensorimotor cortex and caudate nucleus of the rat brain under hypokinesia (HK) lasting 30, 60 and 90 days. At the first stage of HK there were unidirectional changes in the content of NA and DA toward their accumulation by synaptic terminals whereas the level of 5-HT was slightly reduced with respect to normal. The 60-day HK led to varying decreases in the content of all three monoamines as compared with the previous period. Another DA accumulation was recorded by the 90th day of experiment. Meanwhile the content of NA and 5-HT tended toward normal.