McCarren M, Eccles C U
Neurobehav Toxicol Teratol. 1983 Sep-Oct;5(5):527-31.
Upon parturition, Sprague-Dawley dams were administered 1.0 (LL), 2.5 (ML), 5.0 (HL) mg/ml of lead acetate or 1.25 mg/ml sodium acetate (C) in their drinking water. Pups were weaned to tap water at 22 days of age. The developmental pattern of neonatal activity was characterized by monitoring spontaneous activity of single pups for 30 minutes on days 12, 14, 16, 18, 20, and 22, and for one hour in adults. Brains were removed at weaning for subsequent analyses of lead, zinc, and copper. The effects of lead on neonatal activity were considered to be minor because only the ML group differed significantly from C and exhibited hyperactivity on day 16. Adult activity levels, however, were decreased in a dose-dependent fashion. At 22 days of age, whole brain metal analyses revealed a dose-dependent increase in lead levels and a decrease in zinc. These results do not strongly support a hypothesis of lead-induced neonatal hyperactivity.
分娩时，给斯普拉格-道利母鼠饮用含1.0（低剂量组，LL）、2.5（中剂量组，ML）、5.0（高剂量组，HL）mg/ml醋酸铅或1.25 mg/ml醋酸钠（对照组，C）的水。幼崽在22日龄时断奶改饮自来水。通过监测单只幼崽在出生后第12、14、16、18、20和22天的30分钟自发活动以及成年鼠的1小时自发活动，来表征新生鼠活动的发育模式。断奶时取出大脑，用于后续铅、锌和铜的分析。铅对新生鼠活动的影响被认为较小，因为只有中剂量组与对照组有显著差异，且在第16天表现出多动。然而，成年鼠的活动水平呈剂量依赖性下降。在22日龄时，全脑金属分析显示铅水平呈剂量依赖性增加，锌含量降低。这些结果并不有力支持铅诱导新生鼠多动的假说。
