Li P P, Warsh J J, Godse D D
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):751-4. doi: 10.1016/0278-5846(83)90059-3.
Mouse brain DHPG and MHPG turnover rates were estimated by determining their initial rates of disappearance or accumulation following MAO and/or COMT inhibition. Similar turnover estimates of brain DHPG were obtained following MAO or COMT inhibition, which were comparable to the estimated NE turnover obtained from its initial accumulation following MAO plus COMT inhibition. It was estimated that negligible amounts of DHPG were eliminated directly from brain, the majority being cleared through O-methylation. These findings indicate that mouse brain NE is primarily cleared through DHPG formation followed by O-methylation, and also suggest that brain DHPG turnover is more indicative of NE turnover.
通过测定单胺氧化酶（MAO）和/或儿茶酚-O-甲基转移酶（COMT）抑制后小鼠脑内3,4-二羟基苯乙醇（DHPG）和3-甲氧基-4-羟基苯乙二醇（MHPG）的初始消失或积累速率，来估算其周转率。MAO或COMT抑制后获得了类似的脑DHPG周转率估算值，这与MAO加COMT抑制后从其初始积累获得的去甲肾上腺素（NE）周转率估算值相当。据估计，脑内直接消除的DHPG量可忽略不计，大部分通过O-甲基化清除。这些发现表明，小鼠脑内NE主要通过DHPG形成然后O-甲基化清除，也表明脑DHPG周转率更能指示NE周转率。
