Dechelotte P, Kantelip B, Fonck-Cussac Y, Delage J
Ann Pathol. 1983 Dec;3(4):313-9.
The authors report an ultrastructural study about the human fetal bronchiole from seven human fetus which gestational age extend from fifteen to twenty-six weeks. It follows a precedent report concerning the pulmonary acinus. It is thus possible to definite the happening date of the different cellular populations of the bronchiolar layer, their morphology, their distribution, and their differentiation modalities. All those cells have the same endodermal origin from the undifferentiated columnar cell. From the fifteenth week, the three main cellular patterns with a full differentiated aspect are present: ciliated cell, Clara cell, and neurosecretory cell and as a fourth type: the intermediary aspect cell; but the undifferentiated columnar cell is still predominant. From the nineteenth week, those four cellular patterns are predominant. At last, the connection between alveolar and bronchiolar layers is studied at the bronchiolo-alveolar junction. From those data and the literature, the authors consider the bronchiolo-alveolar renewal, in which they think that the Clara cell and/ or an immediate precursor could take a leading part.
作者报告了一项关于7例胎龄从15至26周的人胎儿细支气管的超微结构研究。该研究延续了之前关于肺腺泡的报告。因此，有可能确定细支气管层不同细胞群体的出现时间、它们的形态、分布及其分化方式。所有这些细胞均起源于未分化的柱状细胞，具有相同的内胚层来源。从第15周开始，出现了三种具有完全分化形态的主要细胞类型：纤毛细胞、克拉拉细胞和神经分泌细胞，以及第四种类型：中间形态细胞；但未分化的柱状细胞仍然占主导地位。从第19周开始，这四种细胞类型占主导地位。最后，在细支气管-肺泡连接处研究了肺泡层和细支气管层之间的连接。根据这些数据和文献，作者考虑了细支气管-肺泡更新，他们认为克拉拉细胞和/或其直接前体可能起主导作用。
