Pazdernik T L, Cross R, Nelson S, Samson F, McDonough J
Neurotoxicology. 1983 Winter;4(4):27-34.
Administration of large doses of Soman (2xLD50) to rats protected with TAB, a mixture of trimedoxime (TMB-4), atropine and benactyzine, results in approximately 2-fold reductions of local cerebral glucose utilization (LCGU) in most brain regions. This is in contrast to the marked increase in LCGU that is observed in conjunction with the seizures associated with an LD50 dose of Soman given to unprotected rats. This study reveals that TAB is effective in protecting against Soman-induced seizures, but only at the expense of a severe decrease in LCGU after Soman exposure.
给用三甲双酮（TMB - 4）、阿托品和苯那辛的混合物TAB保护的大鼠注射大剂量梭曼（2倍半数致死剂量），导致大多数脑区的局部脑葡萄糖利用率（LCGU）降低约2倍。这与给未受保护的大鼠注射半数致死剂量梭曼所引发的癫痫发作时观察到的LCGU显著增加形成对比。这项研究表明，TAB能有效预防梭曼诱发的癫痫发作，但代价是梭曼暴露后LCGU会严重下降。
