[Content of hydroperoxides in lipids, superoxide dismutase and glucose-6-phosphate dehydrogenase activity of erythrocytes in alcoholic intoxication].

Content of lipid hydroperoxides was studied in erythrocytes of rats after single and chronic administration of alcohol within 7, 15, 30 and 60 days at a dose of 6 g/kg. Simultaneously, activity of superoxide dismutase as well as activity and kinetic patterns of glucose-6-phosphate dehydrogenase were studied. Phase alterations in content of peroxides and in the enzymatic activity were shown to depend on duration of alcohol intoxication. Inhibition of the enzymatic activity of the mixed type was the cause of a decrease in the glucose-6-phosphate dehydrogenase activity in erythrocytes.