Storozhok S A
Vopr Med Khim. 1983 Nov-Dec;29(6):31-4.
Content of lipid hydroperoxides was studied in erythrocytes of rats after single and chronic administration of alcohol within 7, 15, 30 and 60 days at a dose of 6 g/kg. Simultaneously, activity of superoxide dismutase as well as activity and kinetic patterns of glucose-6-phosphate dehydrogenase were studied. Phase alterations in content of peroxides and in the enzymatic activity were shown to depend on duration of alcohol intoxication. Inhibition of the enzymatic activity of the mixed type was the cause of a decrease in the glucose-6-phosphate dehydrogenase activity in erythrocytes.
研究了大鼠在以6 g/kg的剂量单次和长期给予酒精7、15、30和60天后红细胞中脂质氢过氧化物的含量。同时，研究了超氧化物歧化酶的活性以及葡萄糖-6-磷酸脱氢酶的活性和动力学模式。结果表明，过氧化物含量和酶活性的阶段性变化取决于酒精中毒的持续时间。混合型酶活性的抑制是红细胞中葡萄糖-6-磷酸脱氢酶活性降低的原因。
