Muzzo S, Zvaighaft A, Cañas P
Arch Latinoam Nutr. 1983 Jun;33(2):387-94.
The purpose of this research was to study the binding capacity of estrogens to the sex hormone-binding globulin (SHBG) in mothers and their intrauterine malnourished newborns. Blood samples were obtained from mothers at delivery, and from babies, of the umbilical cord. SHBG was measured according to the method of Mickelson and Petra. It was found in mothers of malnourished babies that the binding capacity of serum protein to dehydrotestosterone (DHT) was significantly decreased in comparison to the controls (10.63 +/- 1.61 vs 13.25 +/- 2.18 micrograms DHT/dl serum, respectively), whereas it was significantly increased in intrauterine malnourished newborns (1.01 +/- 0.24 vs 0.77 +/- 0.18, respectively). These results suggest that SHBG decrease in mothers of intrauterine malnourished newborns occurs due to a decrease in the production of fetal adrenal hormone precursors and may, therefore, be a compensating mechanism to increase placental flow.
本研究的目的是研究雌激素与母亲及其宫内营养不良新生儿的性激素结合球蛋白（SHBG）的结合能力。在分娩时从母亲以及从婴儿的脐带采集血样。根据米克尔森和佩特拉的方法测量SHBG。结果发现，与对照组相比，营养不良婴儿的母亲血清蛋白与脱氢睾酮（DHT）的结合能力显著降低（分别为10.63±1.61与13.25±2.18微克DHT/分升血清），而宫内营养不良的新生儿其结合能力显著增加（分别为1.01±0.24与0.77±0.18）。这些结果表明，宫内营养不良新生儿的母亲体内SHBG降低是由于胎儿肾上腺激素前体的产生减少所致，因此可能是增加胎盘血流量的一种补偿机制。
