对戒断乙醇的大鼠中尼古丁致颤作用的超敏反应。
Hypersensitivity to the tremorogenic action of nicotine in rats withdrawn from ethanol.
作者信息
Gothóni P
出版信息
Med Biol. 1983;61(6):344-5.
The tremorogenic effect of nicotine was studied in control rats and in rats withdrawn for 16-48 h from chronic ethanol administration. The intensity of tremor was measured electronically. Rats withdrawn from ethanol showed a marked hypersensitivity to the tremorogenic action of nicotine. Propranolol abolished the nicotine-induced tremor in the control rats. Propranolol did not, however, reduce the intensity of nicotine-induced tremor in rats withdrawn from ethanol. Thus, the observed hypersensitivity does not seem to be mediated by a sympathetic beta-adrenergic mechanism.
在对照大鼠以及从长期乙醇给药中撤药16 - 48小时的大鼠中研究了尼古丁的致震颤作用。通过电子方式测量震颤强度。从乙醇中撤药的大鼠对尼古丁的致震颤作用表现出明显的超敏反应。普萘洛尔消除了对照大鼠中尼古丁诱导的震颤。然而，普萘洛尔并没有降低从乙醇中撤药的大鼠中尼古丁诱导的震颤强度。因此，观察到的超敏反应似乎不是由交感β - 肾上腺素能机制介导的。
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