Milligan S R, Lytton F D
J Reprod Fertil. 1983 Mar;67(2):373-7. doi: 10.1530/jrf.0.0670373.
Intrauterine instillation of oil, but not saline, induced both a decidual cell reaction and a marked elevation in the uterine PGF-alpha content of suitably sensitized ovariectomized mice. Uterine PGF-alpha concentrations were elevated within 5 min of the oil instillation, reached maximal levels within 30-60 min and then declined to near baseline levels again by 3 h. A similar increase in uterine PGF-alpha content in response to oil instillation was seen in non-sensitized females, although no decidual cell reaction developed. No significant changes in PGE or 6-oxo-PGF-1 content were observed. These results suggest that although the increase in uterine PGF-alpha content is not solely due to the distension of the uterus after intrauterine injection, the increase is not necessarily sufficient to induce a decidual cell reaction.
向适当致敏的去卵巢小鼠子宫内注入油而非生理盐水，可诱导蜕膜细胞反应，并使子宫内前列腺素F-α（PGF-α）含量显著升高。注入油后5分钟内子宫PGF-α浓度升高，30 - 60分钟内达到最高水平，然后在3小时时再次降至接近基线水平。在未致敏的雌性小鼠中，尽管未出现蜕膜细胞反应，但注入油后子宫PGF-α含量也有类似增加。未观察到前列腺素E（PGE）或6-氧代前列腺素F-1（6-oxo-PGF-1）含量有显著变化。这些结果表明，虽然子宫PGF-α含量的增加并非完全由于子宫内注射后的子宫扩张，但这种增加不一定足以诱导蜕膜细胞反应。
