Stern P H, Halloran B P, DeLuca H F, Hefley T J
Am J Physiol. 1983 Apr;244(4):E421-4. doi: 10.1152/ajpendo.1983.244.4.E421.
Radii and ulnae from 19-day fetal rats from normal or vitamin D-deficient mothers were treated with 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, or parathyroid hormone in vitro. Both sets of bones resorbed in response to all three agents. Statistical analysis indicated a purely additive model for the effects of vitamin D status and the bone-resorbing agents, with no evidence for interaction. The results suggest that the impaired calcemic response to parathyroid hormone seen in vitamin D-deficient animals in vivo is not the result of a specific unresponsiveness of vitamin D-deficient bone to parathyroid hormone.
将来自正常或维生素D缺乏母亲的19天龄胎鼠的桡骨和尺骨在体外用25-羟基维生素D3、1,25-二羟基维生素D3或甲状旁腺激素进行处理。两组骨骼均对所有三种药物产生吸收反应。统计分析表明，维生素D状态和骨吸收药物的作用呈现完全相加模型，没有相互作用的证据。结果表明，在维生素D缺乏的动物体内观察到的对甲状旁腺激素的钙调节反应受损，并非是维生素D缺乏的骨骼对甲状旁腺激素存在特异性无反应的结果。
