Grant D M, Tang B K, Kalow W
Clin Pharmacol Ther. 1983 May;33(5):591-602. doi: 10.1038/clpt.1983.80.
Urinary metabolites excreted after oral caffeine were quantified in a healthy sample (n = 68) from the Toronto population by HPLC analyses. The profile of metabolites, assessed by examining particular metabolite ratios, was found to differ widely among subjects. Ratios denoting cytochrome P-450-dependent activities were shown to be interethnically variable between oriental and Caucasian groups, whereas those indicative of xanthine oxidase activity exhibited neither significant interindividual variation nor an ethnic difference. It was also shown that a ratio providing an index of polymorphic N-acetyltransferase activity holds promise as a simple marker for acetylator status in man.
通过高效液相色谱分析对来自多伦多人群的健康样本（n = 68）中口服咖啡因后排泄的尿液代谢物进行了定量分析。通过检查特定代谢物比率评估的代谢物谱在受试者之间差异很大。表示细胞色素P-450依赖性活性的比率在东方人和高加索人群体之间显示出种族间的差异，而那些表明黄嘌呤氧化酶活性的比率既没有显著的个体间差异也没有种族差异。还表明，提供多态性N-乙酰转移酶活性指标的比率有望成为人类乙酰化状态的简单标志物。
