Ferrari C, Romussi M, Rampini P, Benco R, Boghen M, Paracchi A, Frezzati S
J Endocrinol Invest. 1983 Feb;6(1):55-8. doi: 10.1007/BF03350562.
Few data are available on serum free thyroid hormone concentration in patients with T3-toxicosis. In this study total and free T4 and T3 and TBG were evaluated in 35 subjects with T3-toxicosis, including 12 with untreated Graves' disease, 5 Graves' patients on methimazole treatment, 13 with autonomous adenoma, 3 with multinodular goiter, and 2 with subacute thyroiditis. T4, T3, free T4 (FT4), free T3 (FT3) as well as calculated T4/TBG and T3/TBG ratios were significantly higher in patients than in 37 healthy controls. Serum FT4 levels above the normal range were found in 19 subjects with T3-toxicosis (9 with untreated and one with methimazole-treated Graves' disease, 6 with autonomous adenoma, 1 with multinodular goiter and 2 with subacute thyroiditis). These data, together with the few previous reports, indicate that high FT4 levels are present in about half of the patients with so called T3-toxicosis, and that this occurs more frequently in diffuse than nodular goiter. It is suggested that the term T3-toxicosis be used only for those subjects with normal total and free T4.
关于T3中毒患者血清游离甲状腺激素浓度的数据很少。在本研究中，对35例T3中毒患者进行了总T4、游离T4、T3和甲状腺素结合球蛋白（TBG）的评估，其中包括12例未经治疗的格雷夫斯病患者、5例接受甲巯咪唑治疗的格雷夫斯病患者、13例自主性腺瘤患者、3例多结节性甲状腺肿患者和2例亚急性甲状腺炎患者。患者的T4、T3、游离T4（FT4）、游离T3（FT3）以及计算得出的T4/TBG和T3/TBG比值均显著高于37名健康对照者。在19例T3中毒患者中发现血清FT4水平高于正常范围（9例未经治疗的和1例接受甲巯咪唑治疗的格雷夫斯病患者、6例自主性腺瘤患者、1例多结节性甲状腺肿患者和2例亚急性甲状腺炎患者）。这些数据以及之前的少数报告表明，在大约一半的所谓T3中毒患者中存在高FT4水平，并且这种情况在弥漫性甲状腺肿中比结节性甲状腺肿中更常见。建议仅将T3中毒一词用于那些总T4和游离T4正常的患者。
