The antinociceptive effect of ketobemidone in comparison with Ketogin.
作者信息
Larsen J J, Christensen A V
出版信息
Acta Pharmacol Toxicol (Copenh). 1983 Feb;52(2):100-4. doi: 10.1111/j.1600-0773.1983.tb03410.x.
Abstract
The antinociceptive effect of ketobemidone, A 29 (N,N-dimethyl-3,3-diphenyl-l-methyl-alkylamine chloride) and Ketogin (combination of ketobemidone and A 29) has been investigated in mice and rats. The hot plate, grid shock, phenylquinone and Randall-Selitto test were used. Ketobemidone caused antinociception whereas A 29 was without effect. Ketogin was in comparison with ketobemidone more potent. The mechanism of the potentiating effect of A 29 remains to be clarified.
摘要
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