The antinociceptive effect of ketobemidone in comparison with Ketogin.

The antinociceptive effect of ketobemidone, A 29 (N,N-dimethyl-3,3-diphenyl-l-methyl-alkylamine chloride) and Ketogin (combination of ketobemidone and A 29) has been investigated in mice and rats. The hot plate, grid shock, phenylquinone and Randall-Selitto test were used. Ketobemidone caused antinociception whereas A 29 was without effect. Ketogin was in comparison with ketobemidone more potent. The mechanism of the potentiating effect of A 29 remains to be clarified.