血吸虫病：虫卵产生和释放脯氨酸。

Schistosomiasis: proline production and release by ova.

作者信息

Isseroff H, Bock K, Owczarek A, Smith K R

出版信息

J Parasitol. 1983 Apr;69(2):285-9.

Abstract

The production and release of proline was measured in cleaned ova of Schistosoma mansoni. Proline was found to be released at approximately 76 mumoles/100 cc of ova water/hr. This high rate of proline production was found to correlate with extremely active proline synthetic enzymes in the ova. Ornithine-delta-transaminase, which converts ornithine to delta 1-pyrroline-5-carboxylic acid, was found to be twice that of adult schistosomes and over seven times that of rat liver. delta 1-pyrroline-5-carboxylic acid reductase, which converts delta 1-pyrroline-5-carboxylic acid to proline, is also more active than the adult isoenzyme and 35 times more active than the rat liver isoenzyme. These data suggest that proline emanating from the ova may play a role in stimulating fibrosis in the granulomata of schistosomiasis.

摘要

在曼氏血吸虫的洁净虫卵中检测了脯氨酸的产生和释放情况。发现脯氨酸以约76微摩尔/100立方厘米虫卵液/小时的速度释放。研究发现，这种高脯氨酸产生率与虫卵中极其活跃的脯氨酸合成酶相关。将鸟氨酸转化为δ1-吡咯啉-5-羧酸的鸟氨酸δ-转氨酶，其活性是成虫血吸虫的两倍，是大鼠肝脏的七倍多。将δ1-吡咯啉-5-羧酸转化为脯氨酸的δ1-吡咯啉-5-羧酸还原酶，其活性也高于成虫同工酶，是大鼠肝脏同工酶的35倍。这些数据表明，虫卵产生的脯氨酸可能在刺激血吸虫病肉芽肿中的纤维化过程中发挥作用。