Madden A P, Hughes R, Payne J P
Br J Anaesth. 1983;55 Suppl 1:53S-55S.
The records of the recovery pattern of 30 patients given atracurium 0.2-0.9 mg kg-1 were studied. Recovery of the sustained tetanic contraction did not follow an exponential curve as had previously been assumed. However, it did fit a logistic curve so that the plot of logit blockade against time was linear between 99% and 5% blockade. The results support the previous claim that the rate of recovery is independent of dose and that the effects of atracurium are not cumulative in the clinical dose range. The use of the logit transformation may also prove helpful in the analysis of the single twitch contraction during recovery from neuromuscular blockade by atracurium.
对30例给予阿曲库铵0.2 - 0.9 mg·kg⁻¹患者的恢复模式记录进行了研究。持续强直收缩的恢复并不像之前所认为的那样呈指数曲线。然而，它确实符合逻辑斯蒂曲线，因此在99%至5%阻滞之间，对数单位阻滞与时间的关系图呈线性。这些结果支持了之前的观点，即恢复速率与剂量无关，且在临床剂量范围内阿曲库铵的作用不会累积。对数单位变换的应用在分析阿曲库铵所致神经肌肉阻滞恢复过程中的单收缩反应时可能也会有帮助。
