哌仑西平（胃疡平）对离体胃肠道平滑肌的抗胆碱能作用。

Anticholinergic action of pirenzepine (Gastrozepin) on isolated gastrointestinal tract smooth muscles.

作者信息

Ojewole J A

出版信息

Methods Find Exp Clin Pharmacol. 1983;5(3):171-5.

Abstract

The effects of pirenzepine, a new anti-ulcer drug, have been examined on acetylcholine (ACh)-induced contractions of the guinea-pig isolated ileum, rat colon, rainbow lizard rectum, and chick isolated oesophagus. Pirenzepine (10(-9)-10(-6) M), like atropine (2.5 x 10(-10)-10(-6) M) competitively blocked the contractile effects of acetylcholine on all the isolated gastrointestinal tract smooth muscles examined. The pA2 values for pirenzepine and atropine against acetylcholine on all the muscle preparations were not significantly different (P greater than 0.05). It is concluded that the anti-ulcer action of pirenzepine might be due, at least in part, to its (anticholinergic) muscarinic cholinoceptor blocking activity.

摘要

一种新型抗溃疡药物哌仑西平对乙酰胆碱（ACh）诱导的豚鼠离体回肠、大鼠结肠、虹蜥蜴直肠及鸡离体食管收缩的作用已进行了研究。哌仑西平（10⁻⁹ - 10⁻⁶ M）与阿托品（2.5 x 10⁻¹⁰ - 10⁻⁶ M）一样，能竞争性阻断乙酰胆碱对所有所检测的离体胃肠道平滑肌的收缩作用。在所有肌肉标本上，哌仑西平和阿托品对抗乙酰胆碱的pA2值无显著差异（P＞0.05）。得出结论，哌仑西平的抗溃疡作用可能至少部分归因于其（抗胆碱能）毒蕈碱胆碱受体阻断活性。