[Combined effect of FM-100 and several anti-ulcer agents on ulcer induced by ligation of the pylorus in rats].

Single administration of FM-100 (50, 200 mg/kg, i.p.), cimetidine (200, 800 mg/kg, i.d.), pirenzepine (5, 20 mg/kg, i.d.) and ASS (20, 80 mg/kg, p.o.) dose-dependently prevented ulcer formation in pylorus-ligated rats. FM-100 and pirenzepine dose-dependently decreased the volume of gastric juice with a slight increase in the pH, but scarcely influenced pepsin activity. The inhibitory effect of cimetidine on gastric secretion was characterized by an elevation in the pH of the gastric juice. ASS at 80 mg/kg, showing antiulcerogenic activity, had a weak antacidic effect on gastric juice without affecting the volume and pepsin activity. By the combination of FM-100 (50 mg/kg, i.p.) with cimetidine (200 mg/kg, i.d.), pirenzepine (5 mg/kg, i.d.) or ASS (20 mg/kg, p.o.), the preventive effects of these drugs on ulcer formation was augmented; and the combined administration of FM-100 with cimetidine or pirenzepine also enhanced the inhibitory effects of these drugs on gastric secretion.