Carbajal D, Molina V, Valdés S, Arruzazabala L, Más R
National Center for Scientific Research, Havana, Cuba.
J Pharm Pharmacol. 1995 Sep;47(9):731-3. doi: 10.1111/j.2042-7158.1995.tb06732.x.
The anti-ulcer effects of a natural mixture of higher aliphatic primary alcohols, designated D-002, isolated from beeswax, were compared with those of cimetidine on indomethacin-, ethanol-, water-immersion-induced ulcers and on gastric secretion in rats. D-002 (25-50 mg kg-1 p.o.) was similar to cimetidine in dose-dependently reducing the duration of indomethacin-induced ulcers while also being effective in preventing ethanol-induced ulcers, which are not affected by cimetidine. On the other hand, D-002 (100 mg kg-1) moderately decreased the volume of gastric basal secretion in pylorus-ligated rats, but not the acidity. Nevertheless, it inhibited gastric ulcer induced by pylorus-ligation at doses (50 mg kg-1) that were ineffective in decreasing the volume. In addition, 100 mg kg-1 of D-002 prevented the formation of acute gastric ulcers induced in rats by water-immersion stress. The results demonstrate the anti-ulcer activity of the preparation in different experimental models suggesting its potential value for ulcer therapy.
将从蜂蜡中分离得到的一种名为D - 002的高级脂肪族伯醇天然混合物的抗溃疡作用，与西咪替丁对吲哚美辛、乙醇、水浸应激诱导的大鼠溃疡以及胃分泌的影响进行了比较。D - 002（25 - 50毫克/千克，口服）在剂量依赖性地缩短吲哚美辛诱导的溃疡持续时间方面与西咪替丁相似，同时对预防乙醇诱导的溃疡也有效，而西咪替丁对这种溃疡无效。另一方面，D - 002（100毫克/千克）适度降低了幽门结扎大鼠的胃基础分泌量，但未降低胃酸度。然而，它在剂量（50毫克/千克）下抑制了幽门结扎诱导的胃溃疡，而该剂量在降低分泌量方面无效。此外，100毫克/千克的D - 002可预防水浸应激诱导的大鼠急性胃溃疡的形成。结果表明该制剂在不同实验模型中具有抗溃疡活性，提示其在溃疡治疗方面具有潜在价值。
