Canales E S, Cabezas A, Vázquez-Matute L, Zárate A
Fertil Steril. 1978 May;29(5):496-9. doi: 10.1016/s0015-0282(16)43271-1.
Twenty-two infertile and clomiphene-nonresponding patients received a course of clomiphene, 100 mg/day for 5 days, followed 7 days later by an intramuscular injection of 1 mg of estradiol benzoate. The diagnosis of idiopathic chronic anovulation had been established. None of these patients had galactorrhea, hirsutism, or ovarian enlargement. Thirteen of the twenty-two women had surges of both luteinizing hormone and follicle-stimulating hormone after the estradiol injection; the peak gonadotropin levels occurred within 72 hours of the injection. These 13 patients ovulated and pregnancy ensued in 10 of them. The estradiol benzoate injection also elicited a significant increase in serum prolactin levels- This enhanced prolactin release had no apparent effect on the gonadotropin surge. These results suggest that the association of clomiphene and estradiol benzoate potentiates the action of clomiphene and may prove useful in clomiphene nonresponders.
22名不孕且对克罗米芬无反应的患者接受了一个疗程的克罗米芬治疗，每天100毫克，共5天，7天后肌肉注射1毫克苯甲酸雌二醇。特发性慢性无排卵的诊断已经确立。这些患者均无溢乳、多毛或卵巢增大的情况。22名女性中有13名在注射雌二醇后出现促黄体生成素和促卵泡生成素激增；促性腺激素峰值水平在注射后72小时内出现。这13名患者排卵，其中10人随后怀孕。苯甲酸雌二醇注射还使血清催乳素水平显著升高——这种催乳素释放的增强对促性腺激素激增没有明显影响。这些结果表明，克罗米芬和苯甲酸雌二醇联合使用可增强克罗米芬的作用，可能对克罗米芬无反应者有用。
