Witchitz S, Kolsky H, Moisson P
Ann Cardiol Angeiol (Paris). 1983 Dec;32(8):539-43.
Molsidomine (M), a new anti-angina drug, was studied by stress tests in 50 cases of stable angina and clinically in 33 patients not controlled by beta-blockers. One hour after sublingual administration of 2 mg of M. to 10 patients, the work required to cause ST depression of 1 mm (WST1) was increased by 94 per cent (p less than 0.005), the total work was increased by 52 per cent (p less than 0.005) and the maximal ST depression (ST max) was reduced by 45 per cent (p less than 0.01). The resting heart rate was unchanged and the blood pressure dropped mildly. In 4 of the 10 patients with exertional angina even while taking beta-blockers, the synergistic effect of M was remarkable. With a sublingual dose of 1 mg, the WST1 and the ST max are very significantly improved. The effect is even more marked at a dose of 2 mg. With a sublingual or oral of 2 mg, WST1 and ST max are very significantly improved at 1 hour and at 3 hours (p less than 0.005). Data from the literature show a significant anti-ischaemic effect until the 6th hour. In two series of 10 patients, 2 mg of M administered orally were compared to 20 mg of isosorbide dinitrate and to 10 mg of nifedipine at the 2nd hour. The WST1 and ST max were very significantly improved by all three drugs to a similar degree.(ABSTRACT TRUNCATED AT 250 WORDS)
莫索尼定（M）是一种新型抗心绞痛药物，对50例稳定型心绞痛患者进行了负荷试验研究，并对33例未被β受体阻滞剂控制的患者进行了临床研究。对10例患者舌下含服2毫克M后1小时，导致ST段压低1毫米所需的做功量（WST1）增加了94%（p＜0.005），总做功量增加了52%（p＜0.005），最大ST段压低（ST max）降低了45%（p＜0.01）。静息心率未变，血压轻度下降。在10例劳力性心绞痛患者中，即使服用β受体阻滞剂，仍有4例患者M的协同作用显著。舌下含服1毫克剂量时，WST1和ST max有非常显著的改善。2毫克剂量时效果更明显。舌下或口服2毫克时，WST1和ST max在1小时和3小时时有非常显著的改善（p＜0.005）。文献数据显示直到第6小时都有显著的抗缺血作用。在两组各10例患者中，在第2小时将口服2毫克M与20毫克硝酸异山梨酯和10毫克硝苯地平进行比较。三种药物对WST1和ST max均有非常显著的改善，且程度相似。（摘要截短于250字）
