Mahoney B D, Gerdes D, Roller B, Ruiz E
Ann Emerg Med. 1984 Jan;13(1):11-6. doi: 10.1016/s0196-0644(84)80376-5.
The aortic compressor is a device that allows rapid, simple, immediately reversible occlusion of the thoracic aorta, without the aortic dissection required to use an aortic cross-clamp. We evaluated the aortic compressor in a controlled study using a canine hemorrhagic shock model. Twelve mongrel dogs were exsanguinated to a mean arterial pressure (MAP) of 47 mm Hg and maintained at that level for 20 minutes. At that point, all animals had a left lateral thoracotomy. Six study animals had the thoracic aorta occluded at the diaphragm using the compressor. Five minutes after thoracotomy, with or without occlusion, the shed blood was reinfused. Application of the aortic compressor was the only variable. Use of the aortic compressor led to an immediate and statistically significant doubling of the study animals' MAP. The increased afterload of aortic occlusion did not impair cardiac output. The cardiac index of the study animals rose slightly, while that of the control animals fell. At the same time the compressor prevented blood flow to the abdominal aorta. If the canine model can be extrapolated to human application, then the aortic compressor would be expected to enhance perfusion of the heart and brain during hemorrhagic shock, prevent further arterial blood loss from intra-abdominal injury or ruptured abdominal aortic aneurysm, and preserve already diminished cardiac output. Because the aorta does not need to be dissected out to use the compressor, there is no risk of injury to nearby vascular structures.
主动脉压迫器是一种能快速、简便且能立即恢复的阻断胸主动脉的装置,无需像使用主动脉交叉钳那样进行主动脉夹层分离。我们在一项使用犬失血性休克模型的对照研究中评估了主动脉压迫器。12只杂种犬被放血至平均动脉压(MAP)为47毫米汞柱,并维持该水平20分钟。此时,所有动物均进行左外侧开胸手术。6只研究动物使用压迫器在膈肌处阻断胸主动脉。开胸术后5分钟,无论是否进行阻断,均回输 shed blood(此处shed blood可能有误,原文未明确其含义,推测可能是“失血”之类的意思,暂按此翻译)。使用主动脉压迫器是唯一的变量。使用主动脉压迫器使研究动物的MAP立即且在统计学上显著翻倍。主动脉阻断增加的后负荷并未损害心输出量。研究动物的心脏指数略有上升,而对照动物的心脏指数则下降。与此同时,压迫器阻止了血液流向腹主动脉。如果犬模型能够外推至人类应用,那么主动脉压迫器有望在失血性休克期间增强心脏和大脑的灌注,防止因腹部损伤或腹主动脉瘤破裂导致的进一步动脉失血,并维持已经减少的心输出量。由于使用压迫器时无需解剖主动脉,因此不存在损伤附近血管结构的风险。