White R P, Shirasawa Y, Robertson J T
Blood Vessels. 1984;21(1):12-22. doi: 10.1159/000158490.
Alpha-thrombin was applied in cumulative concentrations of 0.001, 0.01, 0.1, 1.0, 10, and/or 100 U/ml to determine peak responses in isolated canine arterial rings. Alpha-thrombin failed to elicit contraction in the mesenteric artery, produced inconsistent effects in the renal artery, and produced biphasic effects (relaxation superseded by contraction) in the coronary and basilar arteries. In the basilar artery the relaxation induced by alpha-thrombin was blocked and the maximal contractions enhanced by reaming the vessel or by substituting heated thrombin for alpha-thrombin. The results support the hypotheses that alpha-thrombin acts on two distinct receptors in the basilar artery and that it is involved in the pathogenesis of cerebral vasospasm.
以0.001、0.01、0.1、1.0、10和/或100 U/ml的累积浓度应用α-凝血酶，以确定离体犬动脉环中的峰值反应。α-凝血酶未能引起肠系膜动脉收缩，在肾动脉中产生不一致的效应，而在冠状动脉和基底动脉中产生双相效应（先是舒张，随后被收缩取代）。在基底动脉中，α-凝血酶诱导的舒张被阻断，并且通过扩管或用加热的凝血酶替代α-凝血酶，最大收缩增强。这些结果支持以下假设：α-凝血酶作用于基底动脉中的两种不同受体，并且它参与了脑血管痉挛的发病机制。
