Gouma D J, Mutum S S, Benjamin I S, Blumgart L H
Br J Surg. 1984 Jan;71(1):72-4. doi: 10.1002/bjs.1800710124.
Intrahepatic bile duct papillomatosis associated with changes of nuclear atypia is described in a young man. Radical excision was performed by left hepatic lobectomy and removal of the common bile duct and left hepatic ducts. Fourteen previous cases of intrahepatic or diffuse intrahepatic and extrahepatic biliary papillomatosis are reviewed. While local recurrence and progression to death from obstructive jaundice and cholangitis is the rule, only two definite cases of malignant change have been reported. Radical surgery may be curative for this rare condition.
一名年轻男性被诊断为肝内胆管乳头状瘤病伴核异型性改变。通过左肝叶切除术、胆总管及左肝管切除术进行了根治性切除。回顾了此前14例肝内或弥漫性肝内及肝外胆管乳头状瘤病的病例。虽然局部复发以及因梗阻性黄疸和胆管炎进展至死亡是常见情况，但仅报告了2例明确的恶变病例。根治性手术可能治愈这种罕见疾病。
