Oohara T, Aono G, Ukawa S, Takezoe K, Johjima Y, Kurosaka H, Asakura R, Tohma H
Cancer. 1984 Jan 1;53(1):162-5. doi: 10.1002/1097-0142(19840101)53:1<162::aid-cncr2820530128>3.0.co;2-q.
When 58 minute gastric cancers less than 5 mm in diameter from 55 patients were classified into 22 of the single group (minute gastric cancer alone) and 36 of the multiple group (associated with other large gastric cancers), the preoperative correct diagnostic rate by x-ray was 22.7% and 11.1% in the single group and in the multiple group, respectively, with a total rate of 15.5%. The diagnostic rate by endoscopy, aided by endoscopic biopsy, was 95.5%, 13.9%, and 44.8%, respectively. Therefore, it appears that endoscopy and endoscopic biopsy are most efficient diagnostic tools for the detection of such minute gastric cancers. Since the detection of the depressed type (IIc) of minute gastric cancers is considered most significant because of their frequent submucosal invasion, their characteristic endoscopic findings are emphasized: (1) irregular and polygonal shape, (2) distinct depression, (3) clear demarcation, (4) nodular margins, and (5) moth-eaten appearance and abrupt thinning of the mucosal folds.
将55例直径小于5mm的58处微小胃癌分为单发型（仅微小胃癌）22处和多发型（合并其他大的胃癌）36处，单发型术前X线正确诊断率为22.7%，多发型为11.1%，总诊断率为15.5%。在内镜活检辅助下，内镜诊断率分别为95.5%、13.9%和44.8%。因此，内镜检查及内镜活检似乎是检测此类微小胃癌最有效的诊断工具。由于凹陷型（IIc型）微小胃癌因常发生黏膜下浸润而被认为意义最为重大，故强调其特征性内镜表现：（1）不规则多边形；（2）明显凹陷；（3）边界清晰；（4）边缘呈结节状；（5）黏膜皱襞呈虫蚀状外观及突然变薄。
