Izui S, Masuda K, Yoshida H
J Immunol. 1984 Feb;132(2):701-4.
Both sexes of the F1 hybrids between SB/Le and NZW mice developed a spontaneous lupus-like disease. Their disease is essentially identical in time course and nature with autoimmune responses that are seen in the F1 hybrids between BXSB and NZW mice. The presence of abnormal Y chromosomes in the SB/Le strain was proved by the finding that the accelerated disease occurred in the F1 hybrid males only when the male parent was SB/Le but not NZW. The acceleration of disease in male F1 hybrids with abnormal Y chromosome was significantly associated with the enhanced formation of gp70 IC but not anti-DNA antibodies. These results indicate that all or almost all of the genetic abnormalities expressed in the BXSB strain are contributed by the SB/Le strain, and the Y chromosome-associated factor enhances the autoimmune response to serum gp70 antigen more markedly than to DNA antigens.
SB/Le和NZW小鼠杂交产生的F1代杂种雌雄两性均会患上自发性狼疮样疾病。它们的疾病在病程和性质上与BXSB和NZW小鼠杂交产生的F1代杂种中出现的自身免疫反应基本相同。通过以下发现证实了SB/Le品系中存在异常Y染色体：只有当雄性亲本为SB/Le而非NZW时，F1代杂种雄性小鼠才会出现加速发展的疾病。具有异常Y染色体的雄性F1代杂种疾病加速与gp70免疫复合物的形成增强显著相关，而与抗DNA抗体无关。这些结果表明，BXSB品系中表达的所有或几乎所有遗传异常均由SB/Le品系导致，并且Y染色体相关因子对血清gp70抗原的自身免疫反应的增强作用比对DNA抗原的增强作用更显著。
