Porpaczy P, Schmidbauer C P, Georgopoulos A, Rameis H
J Urol. 1984 Jan;131(1):169-72. doi: 10.1016/s0022-5347(17)50252-9.
Concentrations of doxorubicin-hydrochloride in renal interstitial fluid were compared following peripheral and intrarenal artery infusion of 2 milligrams per kilogram body weight using a diffusion chamber model. After intra-arterial application, the mean peak concentration in renal interstitial fluid was approximately 30 times higher than that after intravenous infusion (66.49 and 2.38 nanograms per milliliter respectively). After peripheral application, the concentrations in serum and renal interstitial fluid, as well as the cumulative urinary excretion, were measured until day 7 of the experiment, and the pharmacokinetic parameters were calculated. The diffusion chamber model used proved itself to be suitable for simultaneous and continuous measurement of cytostatic drug concentrations in serum and renal interstitial fluid.
采用扩散室模型，比较了以每千克体重2毫克的剂量经外周和肾内动脉输注盐酸多柔比星后肾间质液中的浓度。动脉内给药后，肾间质液中的平均峰值浓度比静脉输注后高约30倍（分别为66.49和2.38纳克/毫升）。外周给药后，在实验的第7天前测量血清和肾间质液中的浓度以及累积尿排泄量，并计算药代动力学参数。所使用的扩散室模型证明适用于同时连续测量血清和肾间质液中细胞毒性药物的浓度。
