Pasyk K A, Cherry G W, Grabb W C, Sasaki G H
Plast Reconstr Surg. 1984 Jan;73(1):69-77. doi: 10.1097/00006534-198401000-00015.
Mast cells were counted in 78 histologic specimens from 70 patients with various vascular malformations showing cellularly dynamic and cellularly adynamic lesions. In growing stages of strawberry hemangiomas, there was an increased number of mast cells (mean 11.0 cells per high-power field in stage III and 23.7 in stage IV), as well as a high number of mast cells in the initial involution of strawberry hemangiomas (stage V, mean 21.0 cells per high-power field). In later involuting stages (stages VI and VII), the number of mast cells decreased (mean 9.3 in stage VI; mean 4.7 in stage VII). In cellularly adynamic lesions, i.e., port wine stains, the mean number of mast cells was 4.8, and in congenital arteriovenous malformations, it was 3.6. In normal skin, the mean number of mast cells was 3.2. In cellular hemangiomas that showed active growth (stages III to IV), the number of mast cells was strikingly low (mean 1.3). It seems that the mast cells are not responsible for the proliferation of the endothelium or for growth of the hemangioma. The markedly increased number of mast cells in the growing stages and initial involuting stage of strawberry hemangiomas parallels the gradual growth of fibrous connective tissue inside the tumor. Mast cells may thus be a precursor of the beginning of the involution of a strawberry hemangioma.
在70例患有各种血管畸形的患者的78份组织学标本中对肥大细胞进行了计数，这些标本显示出细胞动态性和细胞非动态性病变。在草莓状血管瘤的生长阶段，肥大细胞数量增加（III期平均每高倍视野11.0个细胞，IV期为23.7个），在草莓状血管瘤开始消退时（V期，平均每高倍视野21.0个细胞）肥大细胞数量也很多。在后期消退阶段（VI期和VII期），肥大细胞数量减少（VI期平均为9.3个；VII期平均为4.7个）。在细胞非动态性病变，即葡萄酒色斑中，肥大细胞的平均数量为4.8个，在先天性动静脉畸形中为3.6个。在正常皮肤中，肥大细胞的平均数量为3.2个。在显示活跃生长的细胞性血管瘤（III至IV期）中，肥大细胞数量极低（平均1.3个）。肥大细胞似乎与内皮细胞增殖或血管瘤生长无关。草莓状血管瘤生长阶段和开始消退阶段肥大细胞数量的显著增加与肿瘤内部纤维结缔组织的逐渐生长平行。因此，肥大细胞可能是草莓状血管瘤消退开始的前体。
