Risius B, Zelch M G, Graor R A, Geisinger M A, Smith J A, Piraino D W
Radiology. 1984 Feb;150(2):349-55. doi: 10.1148/radiology.150.2.6691087.
Fifty-six patients with acute or chronic arterial or venous thromboembolic occlusions received treatment with low dose (5,000 U per hour) streptokinase via an indwelling intravascular catheter. Successful clot lysis was achieved in 13 of 14 (92%) postprocedural occlusions that were less than one week in age, in 8 of 11 (73%) atherosclerotic occlusions that were less than six weeks in age, in 2 of 3 (67%) emboli from cardiac thrombi, and in all of the pulmonary emboli and superior vena cava occlusions. In the chronic occlusions, successful thrombus lysis occurred less frequently (8 of 21, 38%). Although the initial objective of fibrinolytic therapy is clot lysis, the long term clinical success depends on the diagnosis and treatment of the underlying cause of the thromboembolism.
56例急性或慢性动静脉血栓栓塞性闭塞患者通过留置血管内导管接受低剂量（每小时5000单位）链激酶治疗。在14例病程小于1周的术后闭塞中，13例（92%）成功实现血栓溶解；在11例病程小于6周的动脉粥样硬化闭塞中，8例（73%）成功实现血栓溶解；在3例来自心脏血栓的栓子中，2例（67%）成功实现血栓溶解；所有肺栓塞和上腔静脉闭塞患者均成功实现血栓溶解。在慢性闭塞患者中，成功实现血栓溶解的比例较低（21例中有8例，38%）。尽管溶栓治疗的初始目标是溶解血栓，但长期临床成功取决于对血栓栓塞潜在病因的诊断和治疗。
