Pardo V, Riesgo I, Zilleruelo G, Strauss J
Am J Kidney Dis. 1984 Jan;3(4):264-9. doi: 10.1016/s0272-6386(84)80043-8.
Some patients with minimal change nephrotic syndrome (MCNS) present on biopsy mesangial IgM deposits, which may be associated with mesangial hyperplasia. These patients have been considered as a possible subset with a different response to therapy as well as prognosis and designated as mesangial IgM nephropathy or mesangial proliferative glomerulonephritis. However, the clinical relevance of these biopsy findings has been questioned by others. We reviewed the clinical, biopsy, and follow-up data in 61 MCNS children, 33 with mesangial IgM and 28 free of immunoglobulins. There were no significant differences in response to therapy or prognosis between these two groups. The lack of IgM elution and heterologous in vitro C3 fixation in the biopsies of some MCNS cases with IgM mesangial deposits does not support the possibility that the deposited IgM plays an immunologic role.
一些微小病变型肾病综合征（MCNS）患者在活检时出现系膜IgM沉积，这可能与系膜增生有关。这些患者被认为可能是对治疗反应以及预后不同的一个亚组，并被命名为系膜IgM肾病或系膜增生性肾小球肾炎。然而，其他人对这些活检结果的临床相关性提出了质疑。我们回顾了61例MCNS儿童的临床、活检及随访数据，其中33例有系膜IgM沉积，28例无免疫球蛋白沉积。这两组在治疗反应或预后方面没有显著差异。一些有IgM系膜沉积的MCNS病例活检中缺乏IgM洗脱及异源性体外C3固定，这并不支持沉积的IgM起免疫作用的可能性。
