Erslev A J, Caro J
Am J Med. 1984 Jan;76(1):57-61. doi: 10.1016/0002-9343(84)90750-2.
Erythropoietin titers, measured by bioassay of plasma extracts in hypertransfused mice, were determined in 162 patients with absolute erythrocytosis, and the results were correlated with the clinical diagnosis. Fifty-two patients met the diagnostic criteria for polycythemia vera, and all had low or nonmeasurable erythropoietin titers. Of the remaining 110 patients, 62 were suspected clinically as having secondary polycythemia. However, 15 had low erythropoietin titers, casting doubt on the accuracy of the clinical diagnosis. The pathogenesis of the erythrocytosis in the last 48 patients was unknown, and they were designated clinically as having pure erythrocytosis. However, in 20, the erythropoietin titers were increased, and in 28, the titers were low, suggesting that they belonged to at least two different groups. Using erythropoietin titers in the classification of absolute erythrocytosis, the first group should be added to the category of patients with secondary polycythemia as a subgroup with disease due to idiopathic overproduction of erythropoietin (hypererythropoietinemia or essential erythrocytosis). The second group should be added as a subgroup of patients with primary polycythemia under the term erythremia.
通过对多次输血小鼠血浆提取物进行生物测定来测量促红细胞生成素滴度，对162例绝对红细胞增多症患者进行了测定，并将结果与临床诊断相关联。52例患者符合真性红细胞增多症的诊断标准，且所有患者促红细胞生成素滴度均较低或无法测出。其余110例患者中，62例临床怀疑患有继发性红细胞增多症。然而，15例患者促红细胞生成素滴度较低，这对临床诊断的准确性提出了质疑。最后48例患者红细胞增多症的发病机制不明，临床上将他们诊断为单纯红细胞增多症。然而，其中20例患者促红细胞生成素滴度升高，28例患者滴度较低，这表明他们至少属于两个不同的组。在绝对红细胞增多症的分类中使用促红细胞生成素滴度，第一组应作为因促红细胞生成素特发性过度产生（高促红细胞生成素血症或原发性红细胞增多症）导致疾病的亚组添加到继发性红细胞增多症患者类别中。第二组应作为红细胞增多症这一术语下原发性红细胞增多症患者的亚组添加。
