[Characteristics of morphogenesis of coronary arteriosclerosis in ischemic heart disease].

Characteristics of morphogenesis of plaques in the coronary arteries were studied in persons aged up to 50 years who had died of various forms of ischemic heart disease (IHD). It had been established to be different and in many respects to be dependent upon local and hemodynamic factors originating in connection with IHD. Hyalinized plaques were isolated, in their development a leading role was played by dysoric phenomena in the vascular wall developed because of acute hypoxia in the course of an attack of acute IHD. There were also revealed peculiar fibrous plaques formed in the distal regions of stenosed coronary arteries as a result of the overgrowth of the intima under conditions of hypovolemia. The authors failed to establish the morphogenesis of "old" plaques with lipid deposits.