Osborn K G, Prahalada S, Lowenstine L J, Gardner M B, Maul D H, Henrickson R V
Am J Pathol. 1984 Jan;114(1):94-103.
A syndrome of acquired immunodeficiency within a group of outdoor-housed rhesus macaques (Macaca mulatta) with unusually high mortality has been identified at the California Primate Research Center. The cause of death for most of the affected animals included septicemia and/or chronic diarrhea with wasting, often complicated by other problems. In many cases, multiple or unusual infectious agents were isolated or recognized, including cytomegalovirus, Cryptosporidium spp., and Candida albicans. Septicemias due to usually innocuous agents such as Staphylococcus epidermidis and Alcaligenes faecalis were seen. Two animals developed cutaneous fibrosarcomas. Affected animals had generalized lymphadenopathy and splenomegaly, with depletion of T-cell populations, initially follicular hyperplasia followed by depletion, and absence of plasma cells. This spontaneous disease syndrome in nonhuman primates has similarities to acquired immune deficiency syndrome (AIDS) in humans, providing an animal model for the study of the complex factors modulating the immune system.
在加利福尼亚灵长类动物研究中心，已确认一组圈养在户外的恒河猴（猕猴）出现了一种获得性免疫缺陷综合征，其死亡率异常高。大多数受影响动物的死因包括败血症和/或伴有消瘦的慢性腹泻，常伴有其他并发症。在许多病例中，分离或识别出多种或不常见的感染因子，包括巨细胞病毒、隐孢子虫属和白色念珠菌。还发现了由通常无害的病原体如表皮葡萄球菌和粪产碱杆菌引起的败血症。两只动物患上了皮肤纤维肉瘤。受影响的动物出现全身性淋巴结病和脾肿大，T细胞群体减少，最初是滤泡增生随后是耗竭，且没有浆细胞。这种非人类灵长类动物的自发性疾病综合征与人类获得性免疫缺陷综合征（艾滋病）有相似之处，为研究调节免疫系统的复杂因素提供了一个动物模型。
