Kahana E, Zilber N
Arch Neurol. 1984 Feb;41(2):157-60. doi: 10.1001/archneur.1984.04050140055023.
The incidence of amyotrophic lateral sclerosis (ALS) in Israel was determined for the period 1959 through 1974. A total of 246 patients with ALS was ascertained. The male-female ratio was 1.62:1. The average annual age-adjusted incidence per 100,000 persons increased during this period by 41%. The increase was almost entirely due to a higher rate in persons more than 60 years of age and was greater in women than in men. This led to a decrease in the male-female ratio. The mean age of onset increased from 52.8 to 58.6 years during the same period. The increment in incidence could not be explained by better case ascertainment or increased life expectancy, but greater precision in diagnosis of ALS in the aged may have partially contributed to the increase.
确定了1959年至1974年期间以色列肌萎缩侧索硬化症（ALS）的发病率。共确诊246例ALS患者。男女比例为1.62:1。在此期间，每10万人中经年龄调整的平均年发病率上升了41%。这种上升几乎完全是由于60岁以上人群发病率较高，且女性高于男性。这导致了男女比例下降。同期发病的平均年龄从52.8岁增至58.6岁。发病率的增加无法用病例确诊率提高或预期寿命延长来解释，但老年人群中ALS诊断准确性的提高可能在一定程度上促成了这种增加。
