Denys E H, Jackson J E, Aguilar M J, Wilson A J, Norris F H
Arch Neurol. 1984 Feb;41(2):161-3. doi: 10.1001/archneur.1984.04050140059024.
To test the hypothesis that a serum factor might play a role in the pathogenesis of amyotrophic lateral sclerosis, whole plasma obtained by plasmapheresis from patients with the disease was injected daily intraperitoneally into mice for periods of up to three months. Similar experiments were carried out with an isolated immunoglobulin fraction. Control experiments were carried out simultaneously. The animals were tested electrophysiologically, and histologic examinations of the brain, spinal cord, and peripheral nerves were performed. No ill effects were noted in the animals, and no neurophysiologic or microscopic abnormalities were detected.
为了验证血清因子可能在肌萎缩侧索硬化症发病机制中起作用这一假说，通过血浆置换从该病患者获取的全血浆每天腹腔注射到小鼠体内，持续长达三个月。对分离出的免疫球蛋白组分进行了类似实验。同时进行了对照实验。对动物进行了电生理测试，并对脑、脊髓和周围神经进行了组织学检查。未观察到动物有不良影响，也未检测到神经生理或微观异常。
