Crowe L M, Mouradian R, Crowe J H, Jackson S A, Womersley C
Biochim Biophys Acta. 1984 Jan 11;769(1):141-50. doi: 10.1016/0005-2736(84)90017-8.
The relative effectiveness of a variety of carbohydrates in preserving the structural and functional integrity of membranes at low water activities was studied, using Ca-transporting microsomes from muscle as a model membrane. The order of effectiveness (greatest to lowest) was: trehalose, lactose, maltose, cellobiose, sucrose, glucose, fructose, sorbitol, raffinose, myo-inositol, glycerol. At the highest concentrations of the most effective sugars tested, microsomes were obtained upon rehydration that were similar structurally and functionally to fresh membranes. The least effective carbohydrates, alcohol sugars, all appear to be fusogenic. A structural explanation for relative effectiveness of the sugars was sought, but no clear relationship was found, except that effectiveness does not appear to be related to the number of position of hydroxyl groups available for hydrogen bonding.
利用来自肌肉的钙转运微粒体作为模型膜，研究了多种碳水化合物在低水分活度下保持膜结构和功能完整性的相对有效性。有效性顺序（从最高到最低）为：海藻糖、乳糖、麦芽糖、纤维二糖、蔗糖、葡萄糖、果糖、山梨醇、棉子糖、肌醇、甘油。在所测试的最有效糖类的最高浓度下，复水后获得的微粒体在结构和功能上与新鲜膜相似。最无效的碳水化合物，即糖醇类，似乎都具有融合性。人们试图寻找糖类相对有效性的结构解释，但未发现明确的关系，只是有效性似乎与可用于氢键形成的羟基位置数量无关。
