Dyban P A
Biull Eksp Biol Med. 1984 Jan;97(1):71-2.
Ascites teratocarcinoma OC15S1 represented by embryoid bodies contains two populations of embryocarcinoma cells with different rates of proliferation and levels of differentiation: diffusely dispersed cells (mitotic cycle 11 h, isotope exchange index 32.7%) and cavity-forming cells (14 h and 23.9%, respectively). Upon transplantation of embryoid bodies to allogeneic C57BL mice the growth of teratocarcinoma is inhibited: ascites tumor does not transform to solid; the number of embryoid bodies is 40 times less than in syngeneic mice; the number of necrotic embryoid bodies increases; the animals do not die. Retransplantation of teratocarcinoma cells from allogeneic C57BL mice to syngeneic 129 mice has demonstrated the presence of stem embryocarcinoma cells which retain their oncogenic properties and the mode of differentiation.
以胚体为代表的腹水畸胎癌OC15S1含有两种增殖速率和分化水平不同的胚胎癌细胞群体：分散分布的细胞（有丝分裂周期11小时，同位素交换指数32.7%）和形成腔隙的细胞（分别为14小时和23.9%）。将胚体移植到同种异体C57BL小鼠后，畸胎癌的生长受到抑制：腹水肿瘤不会转变为实体瘤；胚体数量比同基因小鼠少40倍；坏死胚体数量增加；动物不会死亡。将来自同种异体C57BL小鼠的畸胎癌细胞再移植到同基因129小鼠体内，已证明存在保留其致癌特性和分化模式的胚胎癌干细胞。
