Vobecky J, Devroede G, Lacaille J, Water A
Gastroenterology. 1978 Aug;75(2):221-3.
Over a 1 1/2-year period a cluster of 5 patients demonstrated similar characteristics of large bowel cancer, in terms of histological type, occupation in the same manufacturing unit of a carpet factory, sex, young age (less than 50), and a negative familial history of cancer. Therefore, the lifetime occupational familial history of all known cases of colorectal cancer, occurring between 1965 and 1975 in the geographic region where the factory was situated, were reviewed to compare the incidence, histopathological type, and the site distribution of colorectal cancer in the exposed and in a control group. Of 1000 subjects with large bowel cancer so far analyzed 30 have had a positive occupational exposure. A detailed analysis of 12 cases occurring from 1971 to 1975 indicates that the observed age and sex-adjusted relative risk ratio was 10 timer higher among workers in the carpet factory than among other industrial workers. The observed morbidity in the studied group was 11.4 times higher than the expected one.
在1年半的时间里，有一组5名患者表现出相似的大肠癌特征，包括组织学类型、在同一家地毯厂制造部门的职业、性别、年轻（不到50岁）以及癌症家族史阴性。因此，对1965年至1975年期间在该厂所在地理区域发生的所有已知大肠癌病例的终生职业家族史进行了回顾，以比较暴露组和对照组中大肠癌的发病率、组织病理学类型和部位分布。到目前为止，在分析的1000例大肠癌患者中，有30例有阳性职业暴露。对1971年至1975年发生的12例病例的详细分析表明，经年龄和性别调整后，地毯厂工人的相对风险比是其他产业工人的10倍。研究组观察到的发病率比预期发病率高11.4倍。
