Frable W J
Cancer. 1984 Feb 1;53(3 Suppl):671-6. doi: 10.1002/1097-0142(19840201)53:3+<671::aid-cncr2820531313>3.0.co;2-a.
Using a 20- or 22-gauge needle and a 20.0 ml syringe attached to a commercially available syringe pistol, the author performed 853 aspiration biopsies of palpable breast masses during the 9-year period 1974 through 1982. There were 269 diagnoses of breast cancer, 42 suspected cases of cancer, and 496 aspirates reported as benign tumor, inflammation, or another non-neoplastic diagnosis. Twenty-seven cases of carcinoma were not diagnosed from the aspiration biopsy sample. There was one false-positive diagnosis of carcinoma in a patient whose tumor was a cystosarcoma phylloides, benign variant. Forty-six aspirates were considered unsatisfactory, usually because of an insufficient cellular sample. Sensitivity for the diagnosis of breast cancer was 89.0%, while specificity for the absence of breast cancer was 97.0%. Only 13 cases in the group reported as suspicious for carcinoma were proven not to be breast cancer after excisional biopsy and histologic study. The procedure is free of complications, convenient, and cost effective. It provides for evaluation of the patient who has breast cancer on an outpatient basis as well as a full discussion of treatment options prior to intervention.
在1974年至1982年的9年期间，作者使用20号或22号针头以及连接到市售注射器手枪的20.0毫升注射器，对可触及的乳腺肿块进行了853次穿刺活检。其中有269例被诊断为乳腺癌，42例疑似癌症，496例吸出物报告为良性肿瘤、炎症或其他非肿瘤性诊断。27例癌未从穿刺活检样本中诊断出来。有1例患者的肿瘤为叶状囊肉瘤（良性变体），其癌诊断为假阳性。46例吸出物被认为不满意，通常是因为细胞样本不足。乳腺癌诊断的敏感性为89.0%，无乳腺癌的特异性为97.0%。在切除活检和组织学研究后，该组中报告为疑似癌的仅13例被证实不是乳腺癌。该操作无并发症，方便且具有成本效益。它可为门诊乳腺癌患者提供评估，并在干预前充分讨论治疗方案。
