Holten I, Christiansen C
Cancer. 1984 Feb 15;53(4):874-7. doi: 10.1002/1097-0142(19840215)53:4<874::aid-cncr2820530410>3.0.co;2-y.
Irradiation to the neck increases the prevalence of hyperparathyroidism and may cause parathyroid insufficiency. In this study, 35 patients who received therapeutic irradiation to the neck and a control group comprising 19 patients who received radiation to the bladder were studied before, during, and until 2 months after irradiation in order to see whether there were any measurable changes in the parathyroid function. In both groups the serum concentrations of calcium, phosphate and parathyroid hormone were unchanged. Serum protein and albumin decreased in the bladder cancer group. The results support the concept that the parathyroid gland has a low radiation sensitivity, and radiation induced changes may not manifest itself before years after irradiation, due to the low mitotic activity.
颈部照射会增加甲状旁腺功能亢进的发生率，并可能导致甲状旁腺功能不全。在本研究中，对35例接受颈部治疗性照射的患者以及由19例接受膀胱照射的患者组成的对照组，在照射前、照射期间以及照射后2个月进行研究，以观察甲状旁腺功能是否有任何可测量的变化。两组患者的血清钙、磷和甲状旁腺激素浓度均未改变。膀胱癌组的血清蛋白和白蛋白降低。结果支持甲状旁腺对辐射敏感性较低的观点，并且由于有丝分裂活性较低，辐射引起的变化可能在照射后数年才会显现出来。
