集落形成单位 - 脾细胞（CFU - s）抑制剂的便捷来源：胎牛肝脏。
A convenient source of CFU-s inhibitors: the fetal calf liver.
作者信息
Guigon M, Wdzieczak-Bakala J, Mary J Y, Lenfant M
出版信息
Cell Tissue Kinet. 1984 Jan;17(1):49-55. doi: 10.1111/j.1365-2184.1984.tb00567.x.
The presence of a bone-marrow stem-cell inhibitor able to prevent CFU-s entry into DNA synthesis after cytosine arabinoside (Ara-C) treatment has been detected in 7-month-old fetal calf liver. The inhibitory fraction was obtained through ultrafiltration of a delipidated tissue extract powder and purified by BioGel-P-2 chromatography. The elution pattern on Sephadex G10 is similar to that of the bone-marrow inhibitory extract previously obtained from fetal calf bone marrow. It corresponds to a low-molecular-weight molecule (MW less than 2000), devoid of species specificity and having no inhibitory effect on GM-CFC proliferation.
在7月龄胎牛肝脏中检测到一种骨髓干细胞抑制剂，它能够在阿糖胞苷（Ara-C）处理后阻止集落形成单位脾细胞（CFU-s）进入DNA合成阶段。通过对脱脂组织提取物粉末进行超滤获得抑制组分，并通过BioGel-P-2柱色谱法进行纯化。其在Sephadex G10上的洗脱模式与先前从胎牛骨髓中获得的骨髓抑制提取物相似。它对应于一种低分子量分子（分子量小于2000），没有种属特异性，并且对粒细胞-巨噬细胞集落形成细胞（GM-CFC）的增殖没有抑制作用。
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